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Journal article

Selective blockade of CD28 on human T cells facilitates regulation of alloimmune responses

Abstract:

T cells are central to the detrimental alloresponses that develop in autoimmunity and transplantation, with CD28 costimulatory signals being key to T cell activation and proliferation. CTLA4-Ig molecules that bind CD80/86 and inhibit CD28 costimulation offer an alternative immunosuppressive treatment, free from some of the chronic toxicities associated with calcineurin inhibition. However, CD80/86 blockade by CTLA4-Ig also results in the loss of coinhibitory CTLA4 signals that are critical to...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.89381

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Oxford college:
Exeter College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI Insight Journal website
Volume:
2
Issue:
19
Pages:
Article: e89381
Publication date:
2017-10-05
Acceptance date:
2017-08-29
DOI:
ISSN:
2379-3708
Pubs id:
pubs:737106
URN:
uri:07847233-ef16-41c1-80dc-7ebc0dd84e3a
UUID:
uuid:07847233-ef16-41c1-80dc-7ebc0dd84e3a
Local pid:
pubs:737106
Paper number:
19
Language:
English

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