Journal article
Selective blockade of CD28 on human T cells facilitates regulation of alloimmune responses
- Abstract:
-
T cells are central to the detrimental alloresponses that develop in autoimmunity and transplantation, with CD28 costimulatory signals being key to T cell activation and proliferation. CTLA4-Ig molecules that bind CD80/86 and inhibit CD28 costimulation offer an alternative immunosuppressive treatment, free from some of the chronic toxicities associated with calcineurin inhibition. However, CD80/86 blockade by CTLA4-Ig also results in the loss of coinhibitory CTLA4 signals that are critical to...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- JCI Insight Journal website
- Volume:
- 2
- Issue:
- 19
- Article number:
- e89381
- Publication date:
- 2017-10-05
- Acceptance date:
- 2017-08-29
- DOI:
- ISSN:
-
2379-3708
- Pmid:
-
28978798
Item Description
- Language:
- English
- Pubs id:
-
pubs:737106
- UUID:
-
uuid:07847233-ef16-41c1-80dc-7ebc0dd84e3a
- Local pid:
- pubs:737106
- Source identifiers:
-
737106
- Deposit date:
- 2017-11-13
Terms of use
- Copyright holder:
- American Society for Clinical Investigation
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 American Society for Clinical Investigation.
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