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Journal article

Rapid neutrophil mobilization by VCAM-1+ endothelial cell-derived extracellular vesicles

Abstract:
Aims Acute myocardial infarction rapidly increases blood neutrophils (<2 h). Release from bone marrow, in response to chemokine elevation, has been considered their source, but chemokine levels peak up to 24 h after injury, and after neutrophil elevation. This suggests that additional non-chemokine-dependent processes may be involved. Endothelial cell (EC) activation promotes the rapid (<30 min) release of extracellular vesicles (EVs), which have emerged as an important means... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cvr/cvac012

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0003-4620-6373
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0003-3228-2172
More by this author
Role:
Author
ORCID:
0000-0002-5817-2003

Contributors

Nuffield Benefaction for Medicine and the Wellcome Institutional Strategic Support Fund (ISSF) More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular Research Journal website
Place of publication:
England
Publication date:
2022-02-04
Acceptance date:
2022-01-28
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Pmid:
35134856
Language:
English
Keywords:
Pubs id:
1239146
Local pid:
pubs:1239146
Deposit date:
2022-07-26

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