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Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns

Abstract:

Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-10121-3

Authors


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Role:
Author
ORCID:
0000-0003-4484-7433
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Name:
National Institutes of Health
Grant:
R01-AI101713
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Name:
Wellcome Trust
Grant:
093956/Z/10/Z
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
10
Article number:
2665
Publication date:
2019-06-17
Acceptance date:
2019-04-17
DOI:
EISSN:
2041-1723
Pmid:
31209259
Language:
English
Pubs id:
pubs:1020372
UUID:
uuid:075414ce-ea13-4912-a0bc-53ab3613073d
Local pid:
pubs:1020372
Source identifiers:
1020372
Deposit date:
2019-07-22

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