Journal article
Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation
- Abstract:
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Memory T cells are characterized by their rapid transcriptional programs upon re-stimulation. This transcriptional memory response is facilitated by permissive chromatin, but exactly how the permissive epigenetic landscape in memory T cells integrates incoming stimulatory signals remains poorly understood. By genome-wide ChIP-sequencing ex vivo human CD4+ T cells, here, we show that the signaling enzyme, protein kinase C theta (PKC-θ) directly relays stimulatory signals to chromatin by bindin...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.7MB)
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- Publisher copy:
- 10.1242/jcs.181248
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Authors
Funding
+ National Health and Medical Research Council
More from this funder
Funding agency for:
Seddiki, N
Grant:
APP1025718
+ National Health and Medical Research Council
More from this funder
Funding agency for:
Rao, S
Grant:
APP1025718
Bibliographic Details
- Publisher:
- Company of Biologists Publisher's website
- Journal:
- Journal of Cell Science Journal website
- Volume:
- 129
- Issue:
- 12
- Pages:
- 2448-2461
- Publication date:
- 2018-05-05
- Acceptance date:
- 2016-04-21
- DOI:
- EISSN:
-
1477-9137
- ISSN:
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0021-9533
- Pmid:
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27149922
- Source identifiers:
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619863
Item Description
- Language:
- English
- Pubs id:
-
pubs:619863
- UUID:
-
uuid:074a0cf3-c95b-4ef5-ab83-8e06b51a4b6e
- Local pid:
- pubs:619863
- Deposit date:
- 2018-12-07
Terms of use
- Copyright holder:
- Li, et al
- Copyright date:
- 2018
- Notes:
-
© 2016. Published by The Company of Biologists Ltd
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
- Licence:
- CC Attribution (CC BY)
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