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Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation

Abstract:

Memory T cells are characterized by their rapid transcriptional programs upon re-stimulation. This transcriptional memory response is facilitated by permissive chromatin, but exactly how the permissive epigenetic landscape in memory T cells integrates incoming stimulatory signals remains poorly understood. By genome-wide ChIP-sequencing ex vivo human CD4+ T cells, here, we show that the signaling enzyme, protein kinase C theta (PKC-θ) directly relays stimulatory signals to chromatin by bindin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1242/jcs.181248

Authors


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ORCID:
0000-0003-1660-4477
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
ORCID:
0000-0001-6617-5995
Sutcliffe, EL More by this author
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Publisher:
Company of Biologists Publisher's website
Journal:
Journal of Cell Science Journal website
Volume:
129
Issue:
12
Pages:
2448-2461
Publication date:
2018-05-05
Acceptance date:
2016-04-21
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
Pubs id:
pubs:619863
URN:
uri:074a0cf3-c95b-4ef5-ab83-8e06b51a4b6e
UUID:
uuid:074a0cf3-c95b-4ef5-ab83-8e06b51a4b6e
Local pid:
pubs:619863
Language:
English

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