Journal article icon

Journal article

Insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3) and breast cancer risk: Observational and Mendelian randomization analyses with ~430,000 women

Abstract:

Background:
Epidemiological evidence supports a positive association between circulating insulin-like growth factor-1 (IGF-1) concentrations and breast cancer risk, but both the magnitude and causality of this relationship are uncertain. We conducted observational analyses with adjustment for regression dilution bias, and Mendelian randomization (MR) analyses allowed for causal inference.


Patients and Methods:
We investigated the ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.annonc.2020.01.066

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
LEAP 205212/Z/16/Z
More from this funder
Name:
Cancer Research UK
Grant:
19170
Publisher:
Elsevier
Journal:
Annals of Oncology More from this journal
Volume:
31
Issue:
5
Pages:
641-649
Publication date:
2020-03-10
Acceptance date:
2020-01-24
DOI:
EISSN:
1569-8041
ISSN:
0923-7534
Language:
English
Keywords:
Pubs id:
1083773
Local pid:
pubs:1083773
Deposit date:
2020-01-29

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP