Back to Search

Journal article

Insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3) and breast cancer risk: Observational and Mendelian randomization analyses with ~430,000 women

Abstract:: Background:
Epidemiological evidence supports a positive association between circulating insulin-like growth factor-1 (IGF-1) concentrations and breast cancer risk, but both the magnitude and causality of this relationship are uncertain. We conducted observational analyses with adjustment for regression dilution bias, and Mendelian randomization (MR) analyses allowed for causal inference.

Patients and Methods:
We investigated the ...
Expand abstract
Collapse abstract

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Murphy, N., Knuppel, A., Papadimitriou, N., Martin, R. M., Tsilidis, K. K., Smith-Byrne, K., Fensom, G., Perez-Cornago, A., Travis, R. C., Key, T. J., & Gunter, M. J. (2020). Insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3) and breast cancer risk: Observational and Mendelian randomization analyses with ~430,000 women. Annals of Oncology, 31(5), 641–649.

MLA Style

Murphy, N., et al. “Insulin-like Growth Factor-1 (IGF-1), Insulin-like Growth Factor-Binding Protein-3 (IGFBP-3) and Breast Cancer Risk: Observational and Mendelian Randomization Analyses with ~430,000 Women.” Annals of Oncology, vol. 31, no. 5, Elsevier, 2020, pp. 641–49.

Chicago Style

Murphy, N, A Knuppel, N Papadimitriou, RM Martin, KK Tsilidis, K Smith-Byrne, G Fensom, et al. 2020. “Insulin-like Growth Factor-1 (IGF-1), Insulin-like Growth Factor-Binding Protein-3 (IGFBP-3) and Breast Cancer Risk: Observational and Mendelian Randomization Analyses with ~430,000 Women.” Annals of Oncology 31 (5): 641–49.
Tweet
Print

Access Document

Files:: Murphy_et_al_Insulin-l...

(Version of record, 1.1MB)

Publisher copy:: 10.1016/j.annonc.2020.01.066

Authors

+ Murphy, N More by this author

Role:

Author

+ Knuppel, A More by this author

Institution:

University of Oxford

Division:

MSD

Department:

Nuffield Department of Population Health

Sub department:

Cancer Epidemiology Unit

Role:

Author

+ Papadimitriou, N More by this author

Role:

Author

+ Martin, RM More by this author

Role:

Author

+ Tsilidis, KK More by this author

Role:

Author

More authors...

Funding

+ Wellcome Trust More from this funder

Grant:

LEAP 205212/Z/16/Z

+ Cancer Research UK More from this funder

Grant:

19170

Bibliographic Details

Publisher:: Elsevier Publisher's website
Journal:: Annals of Oncology Journal website
Volume:: 31
Issue:: 5
Pages:: 641-649
Publication date:: 2020-03-10
Acceptance date:: 2020-01-24
DOI:: 10.1016/j.annonc.2020.01.066
EISSN:: 1569-8041
ISSN:: 0923-7534

Item Description

Language:: English
Keywords:: breast cancer

FFR

insulin-like growth factor-binding protein-3 (IGFBP-3)

Mendelian randomization

insulin-like growth factor-1 (IGF-1)

observational
Pubs id:: 1083773
Local pid:: pubs:1083773
Deposit date:: 2020-01-29

Terms of use

Copyright holder:: European Society for Medical Oncology
Copyright date:: 2020
Rights statement:: © 2020 Published by Elsevier Ltd on behalf of European Society for Medical Oncology. This is an open access article under the CC BY-NC-ND IGO license.

Licence:: CC Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

Metrics

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP