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The association between blood eosinophils and risk and treatment outcome in COPD is not dichotomised

Abstract:

We would like to congratulate Bafadhel et al on their excellent paper examining the response to Budesonide and blood eosinophils counts (on line version 10th Jan) in COPD. In clearly demonstrating the continuous nature of the relationship between blood eosinophil count and the risk of exacerbations as well the benefit of inhaled corticosteroids in COPD, they have helped clarify a point that we alluded to in our original paper1 that the nature of the response is “graded” dependent on the eosin...

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Publication status:
Published
Peer review status:
Reviewed (Other)
Version:
Accepted manuscript

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Publisher copy:
10.1016/s2213-2600(18)30137-1

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Oxford college:
St Edmund Hall
ORCID:
0000-0002-4288-5973
Locantore, N More by this author
GlaxoSmithKline More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Lancet Respiratory Medicine Journal website
Volume:
6
Issue:
5
Pages:
e18
Publication date:
2018-04-05
Acceptance date:
2018-03-15
DOI:
EISSN:
2213-2619
ISSN:
2213-2600
Pubs id:
pubs:842699
URN:
uri:07435dbd-8174-4b41-91a7-1d4a8a93a6fc
UUID:
uuid:07435dbd-8174-4b41-91a7-1d4a8a93a6fc
Local pid:
pubs:842699

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