Journal article icon

Journal article

The ALSFRS as an outcome measure in therapeutic trials and its relationship to symptom onset

Abstract:

The reduction in ALS Functional Rating Score (ALSFRS) from reported symptom onset to diagnosis is used to estimate rate of disease progression. ALSFRS decline may be non-linear or distorted by drop-outs in therapeutic trials, reducing the reliability of change in slope as an outcome measure. The PRO-ACT database uniquely allows such measures to be explored using historical data from negative therapeutic trials. The decline of functional scores was analysed in 18 pooled trials, comparing rates...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.3109/21678421.2016.1140786

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Publisher:
Taylor and Francis Publisher's website
Journal:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Journal website
Volume:
17
Issue:
5-6
Pages:
1-12
Publication date:
2016-02-04
Acceptance date:
2015-11-30
DOI:
EISSN:
2167-9223
ISSN:
2167-8421
Source identifiers:
605863
Language:
English
Keywords:
Pubs id:
pubs:605863
UUID:
uuid:07410f14-6eba-405c-9455-c1a456017e7f
Local pid:
pubs:605863
Deposit date:
2016-08-01

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP