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Journal article

NF-κB regulates mica gene transcription in endothelial cell through a genetically inhibitable control site

Abstract:

Endothelial cells form a barrier between blood and the underlying vessel wall, which characteristically demonstrates inflammatory damage in atherosclerotic disease. MICA is a highly polymorphic ligand for the activating immune receptor NKG2D and can be expressed on endothelial cells. We hypothesized that damaged vessel walls, such as those involved in atherosclerosis, might express MICA, which could contribute to the vascular immunopathology. Immune activation...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
CCMP
Oxford college:
Queens College
Role:
Author
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Name:
PG/11/4/28645/British Heart Foundation
More from this funder
Name:
G116/165/Medical Research Council
Publisher:
American Society for Biochemistry and Molecular Biology
Journal:
Journal of biological chemistry More from this journal
Volume:
287
Issue:
6
Pages:
4299-4310
Publication date:
2011-12-14
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
22170063
Language:
English
Keywords:
Pubs id:
pubs:252129
UUID:
uuid:073dfc2e-dc92-409d-94cb-c6d02d9b8793
Local pid:
pubs:252129
Source identifiers:
252129
Deposit date:
2017-11-13

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