- Abstract:
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Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity, which can amplify circulating GC concentrations. Therefore, 11β-HSD1 could modulate the impact of GCs on BAT function. This study investigated how 11β-HSD1 regulates ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Version of record
- Files:
-
-
(pdf, 1.4mb)
-
- Publisher copy:
- 10.1210/en.2016-1722
-
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- Grant:
- David Philips Fellowship GGL-BB/G023468/1
- Publisher:
- Oxford University Press (OUP) Publisher's website
- Journal:
- Endocrinology Journal website
- Volume:
- 158
- Issue:
- 6
- Pages:
- 1964-1976
- Publication date:
- 2017-06-01
- Acceptance date:
- 2017-03-21
- DOI:
- EISSN:
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1945-7170
- ISSN:
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0013-7227
- Pubs id:
-
pubs:689153
- URN:
-
uri:070d53df-a219-4ea5-9cd1-b8c363d4f383
- UUID:
-
uuid:070d53df-a219-4ea5-9cd1-b8c363d4f383
- Local pid:
- pubs:689153
- Language:
- English
- Keywords:
- Copyright holder:
- Doig et.al.
- Copyright date:
- 2017
- Notes:
- This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).
Journal article
11β-HSD1 modulates the set point of brown adipose tissue response to glucocorticoids in male mice
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