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11β-HSD1 modulates the set point of brown adipose tissue response to glucocorticoids in male mice

Abstract:

Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity, which can amplify circulating GC concentrations. Therefore, 11β-HSD1 could modulate the impact of GCs on BAT function. This study investigated how 11β-HSD1 regulates ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
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Publisher copy:
10.1210/en.2016-1722

Authors


Fletcher, RS More by this author
Morgan, SA More by this author
McCabe, EL More by this author
Larner, DP More by this author
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Grant:
Senior Fellowship GGL-104612/Z/14/Z
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Grant:
Advanced Grant PMS-20090506
Publisher:
Oxford University Press (OUP) Publisher's website
Journal:
Endocrinology Journal website
Volume:
158
Issue:
6
Pages:
1964-1976
Publication date:
2017-06-01
Acceptance date:
2017-03-21
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
Pubs id:
pubs:689153
URN:
uri:070d53df-a219-4ea5-9cd1-b8c363d4f383
UUID:
uuid:070d53df-a219-4ea5-9cd1-b8c363d4f383
Local pid:
pubs:689153

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