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Initial identification of a blood-based chromosome conformation signature for aiding in the diagnosis of amyotrophic lateral sclerosis

Abstract:
Background The identification of blood-based biomarkers specific to the diagnosis of amyotrophic lateral sclerosis (ALS) is an active field of academic and clinical research. While inheritance studies have advanced the field, a majority of patients do not have a known genetic link to the disease, making direct sequence-based genetic testing for ALS difficult. The ability to detect biofluid-based epigenetic changes in ALS would expand the relevance of using genomic information... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Authors


More from this funder
Name:
Motor Neurone Disease Association
Funding agency for:
Turner, M
Grant:
Lady Edith Wolfson Senior Clinical Fellowship (MR/K01014X/1
More from this funder
Name:
Medical Research Council
Funding agency for:
Turner, M
Grant:
Lady Edith Wolfson Senior Clinical Fellowship (MR/K01014X/1
MR/L002167/1
Publisher:
Elsevier
Journal:
EBioMedicine More from this journal
Volume:
33
Pages:
169-184
Publication date:
2018-06-23
Acceptance date:
2018-06-12
DOI:
ISSN:
2352-3964
Pmid:
29941342
Language:
English
Pubs id:
pubs:859936
UUID:
uuid:0707df80-621e-42ca-ae6b-da1594d883cb
Local pid:
pubs:859936
Source identifiers:
859936
Deposit date:
2018-10-04

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