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Deoxyguanosine is a TLR7 agonist

Abstract:

Toll-like receptor 7 (TLR7) is an innate immune sensor for single-strand RNA (ssRNA). Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine and is activated when both guanosine and ssRNA bind. The nucleoside binding site also accommodates imidazoquinoline derivatives such as R848, which activates TLR7 in the absence of ssRNA. Here, we report that deoxyguanosine (dG) triggered cytokine production in murine bone marrow derived macrophages...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/eji.201948151

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
ORCID:
0000-0003-3841-835X
Publisher:
Wiley
Journal:
European Journal of Immunology More from this journal
Volume:
50
Issue:
1
Pages:
56-62
Publication date:
2019-10-14
Acceptance date:
2019-10-14
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Pmid:
31608988
Language:
English
Keywords:
Pubs id:
pubs:1063768
UUID:
uuid:0700bbb9-2b8c-4cfe-b365-ec44e2a48b4f
Local pid:
pubs:1063768
Source identifiers:
1063768
Deposit date:
2019-11-12

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