Individual variations in “brain age” relate to early life factors more than to longitudinal brain change
Brain age is a widely used index for quantifying individuals’ brain health as deviation from a normative brain aging trajectory. Higher than expected brain age is thought partially to reflect above-average rate of brain aging. Here, we explicitly tested this assumption in two independent large test datasets (UK Biobank [main] and Lifebrain [replication]; longitudinal observations ≈ 2,750 and 4,200), by assessing the relationship between cross-sectional and longitudinal estimates of brain age....Expand abstract
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