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Individual variations in “brain age” relate to early life factors more than to longitudinal brain change

Abstract:

Brain age is a widely used index for quantifying individuals’ brain health as deviation from a normative brain aging trajectory. Higher than expected brain age is thought partially to reflect above-average rate of brain aging. Here, we explicitly tested this assumption in two independent large test datasets (UK Biobank [main] and Lifebrain [replication]; longitudinal observations ≈ 2,750 and 4,200), by assessing the relationship between cross-sectional and longitudinal estimates of brain age....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.69995

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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
10
Issue:
2021
Article number:
e69995
Publication date:
2021-11-10
Acceptance date:
2021-10-04
DOI:
EISSN:
2050-084X
Language:
English
Keywords:
Pubs id:
1160365
Local pid:
pubs:1160365
Deposit date:
2021-02-09

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