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Determining possible shared genetic architecture between myopia and primary open-angle glaucoma

Abstract:

Purpose:To determine genetic correlations between common myopia and primary open-angle glaucoma (POAG). Methods:We tested the association of myopia polygenic risk scores (PRSs) with POAG and POAG endophenotypes using two studies: the Australian & New Zealand Registry of Advanced Glaucoma (ANZRAG) study comprising 798 POAG cases with 1992 controls, and the Rotterdam Study (RS), a population-based study with 11,097 participants, in which intraocular pressure (IOP) and optic disc parameter m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1167/iovs.18-26231

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Publisher:
Association for Research in Vision and Ophthalmology
Journal:
Investigative Ophthalmology and Visual Science More from this journal
Volume:
60
Issue:
8
Pages:
3142-3149
Publication date:
2019-07-01
Acceptance date:
2019-06-04
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
Pmid:
31323684
Language:
English
Keywords:
Pubs id:
pubs:1033661
UUID:
uuid:06e78623-0f2f-42db-9c5a-2afa8e7151ac
Local pid:
pubs:1033661
Source identifiers:
1033661
Deposit date:
2019-11-19

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