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Thesis

Computational studies of lipopolysaccharide interactions with membrane transporters

Abstract:

Lipopolysaccharide (LPS) lipids compose the outer leaflet of the outer membrane in pathogenic Gram-negative bacteria and are chiefly responsible for host-immune responses. Therefore, the membrane proteins which interact with LPS as well as the transport system for LPS, the Lpt system, represents a class of extremely important drug targets. The focus of this thesis is to employ molecular dynamics studies to examine the effects of LPS binding upon the Lpt complex at every stage of the transp...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
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Name:
BBSRC
Grant:
BB/M011224/1
Programme:
The Oxford Interdisciplinary Bioscience Doctoral Training Partnership
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:

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