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Comparative effectiveness of immune-checkpoint inhibitors for previously treated advanced non-small cell lung cancer - A systematic review and network meta-analysis of 3024 participants

Abstract:

Role of PD-L1 expression to guide immunotherapies in previously treated advanced NSCLC remains unclear and there is a lack of data comparing immune checkpoint inhibitors (ICIs) with each other. This network meta-analysis (NMA) aims to compare survival with ICIs to docetaxel and perform indirect comparisons between ICIs in the PD-L1 unselected population and by PD-L1 expression levels.PubMed was searched and study screening was performed by two independent reviewers. NMA of survival outcomes i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.lungcan.2017.11.017

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care Health Sciences
Haaland, B More by this author
Publisher:
Elsevier Publisher's website
Journal:
Lung Cancer Journal website
Volume:
115
Pages:
84-88
Publication date:
2017-11-22
Acceptance date:
2017-11-19
DOI:
EISSN:
1872-8332
ISSN:
0169-5002
Pubs id:
pubs:813690
URN:
uri:06bfa13a-830e-47c9-aa1e-cf1468764f70
UUID:
uuid:06bfa13a-830e-47c9-aa1e-cf1468764f70
Local pid:
pubs:813690

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