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Association between more intensive vs less intensive blood pressure lowering and risk of mortality in chronic kidney disease stages 3 to 5: A systematic review and meta-analysis.

Abstract:

Importance

Trials in patients with hypertension have demonstrated that intensive blood pressure (BP) lowering reduces the risk of cardiovascular disease and all-cause mortality but may increase the risk of chronic kidney disease (CKD) incidence and progression. Whether intensive BP lowering is associated with a mortality benefit in patients with prevalent CKD remains unknown.

Objectives

To conduct a systematic review and meta-analysis of randomized clinical trials...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1001/jamainternmed.2017.4377

Authors


More from this funder
Name:
National Institutes of Health
Grant:
R01AG046206
More from this funder
Name:
American Heart Association
Publisher:
American Medical Association
Journal:
JAMA Internal Medicine More from this journal
Volume:
177
Issue:
10
Pages:
1498-1505
Publication date:
2017-09-05
Acceptance date:
2017-07-03
DOI:
EISSN:
2168-6114
ISSN:
2168-6106
Pmid:
28873137
Language:
English
Keywords:
Pubs id:
pubs:725894
UUID:
uuid:069f8641-108a-48e1-9fe4-74daaac1ee45
Local pid:
pubs:725894
Source identifiers:
725894
Deposit date:
2017-09-21

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