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Epigenetic regulation of sensory axon regeneration after spinal cord injury

Abstract:

Axon regeneration is hindered by a decline of intrinsic axon growth capability in mature neurons. Reversing this decline is associated with the induction of a large repertoire of regeneration-associated genes (RAGs), but the underlying regulatory mechanisms of the transcriptional changes are largely unknown. Here, we establish a correlation between diminished axon growth potential and histone 4 (H4) hypoacetylation. When neurons are triggered into a growth sta...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1523/jneurosci.0589-13.2013

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0002-0152-3642
More by this author
Role:
Author
ORCID:
0000-0003-4216-5607
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Grant:
R01 NS073596
NS073596
Publisher:
Society for Neuroscience Publisher's website
Journal:
Journal of Neuroscience Journal website
Volume:
33
Issue:
50
Pages:
19664-19676
Publication date:
2013-12-11
Acceptance date:
2013-11-06
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Pmid:
24336730
Language:
English
Keywords:
Pubs id:
pubs:456138
UUID:
uuid:0691e896-7e3e-4d99-a80a-cd487539956a
Local pid:
pubs:456138
Source identifiers:
456138
Deposit date:
2018-02-02

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