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Hebbian plasticity requires compensatory processes on multiple timescales

Abstract:

We review a body of theoretical and experimental research on Hebbian and homeostatic plasticity, starting from a puzzling observation: while homeostasis of synapses found in experiments is a slow compensatory process, most mathematical models of synaptic plasticity use rapid compensatory processes (RCPs). Even worse, with the slow homeostatic plasticity reported in experiments, simulations of existing plasticity models cannot maintain network stability unless further control mechanisms are im...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1098/rstb.2016.0259

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
ORCID:
0000-0003-1883-644X
Gerstner, W More by this author
Publisher:
Royal Society Publisher's website
Journal:
Philosophical Transactions B: Biological Sciences Journal website
Volume:
372
Issue:
1715
Pages:
Article: 20160259
Publication date:
2017-01-16
Acceptance date:
2016-11-09
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
Pubs id:
pubs:682222
URN:
uri:0684cca4-1f86-43df-8d28-fa230de457e4
UUID:
uuid:0684cca4-1f86-43df-8d28-fa230de457e4
Local pid:
pubs:682222

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