Journal article
Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans.
- Abstract:
-
The 18kDa Translocator Protein (TSPO) is the most commonly used tissue-specific marker of inflammation in positron emission tomography (PET) studies. It is expressed in myeloid cells such as microglia and macrophages, and in rodent myeloid cells expression increases with cellular activation. We assessed the effect of myeloid cell activation on TSPO gene expression in both primary human and rodent microglia and macrophages in vitro, and also measured TSPO radioligand binding with 3H-PBR28 in p...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Imanova Centre for Imaging Sciences
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UK Multiple Sclerosis Society
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Abbvie
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Medical Research Council
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Bibliographic Details
- Publisher:
- SAGE Publications Publisher's website
- Journal:
- Journal of Cerebral Blood Flow and Metabolism Journal website
- Volume:
- 37
- Issue:
- 8
- Pages:
- 2679-2690
- Publication date:
- 2017-05-01
- Acceptance date:
- 2017-04-18
- DOI:
- ISSN:
-
1559-7016 and 0271-678X
- Pmid:
-
28530125
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:718605
- UUID:
-
uuid:068413c1-95c5-4fad-81d8-e5b424162448
- Local pid:
- pubs:718605
- Source identifiers:
-
718605
- Deposit date:
- 2018-01-15
Terms of use
- Copyright holder:
- Taylor et al
- Copyright date:
- 2017
- Notes:
- © Author(s) 2017 This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
- Licence:
- CC Attribution (CC BY)
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