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Journal article

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

Abstract:

Chronic sleep disturbances, associated with cardio-metabolic diseases, psychiatric disorders and all-cause mortality1,2, affect 25-30% of adults worldwide. While environmental factors contribute importantly to self-reported habitual sleep duration and disruption, these traits are heritable4-9, and gene identification should improve our understanding of sleep function, mechanisms linking sleep to disease, and development of novel therapies. We report single and multi-trait genome-wide associat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ng.3749

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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
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Grant:
RS),R01DK102696(RS
R01DK107859(RS),R21HL121728(RS),F32DK102323(JML), 413R01HL113338(JML,SR
FS),R01DK105072(RS
FS), 414T32HL007567(JL),HG003054(XZ
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Grant:
Research Infrastructure Fund
Wellcome Trust More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
49
Pages:
274–281
Publication date:
2016-12-19
Acceptance date:
2016-11-25
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
662099
Keywords:
Pubs id:
pubs:662099
UUID:
uuid:067bf112-a954-466d-8df0-f57debf75b52
Local pid:
pubs:662099
Deposit date:
2016-11-30

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