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New Insights into Acquisition, Boosting, and Longevity of Immunity to Malaria in Pregnant Women

Abstract:

Background. How antimalarial antibodies are acquired and maintained during pregnancy and boosted after reinfection with Plasmodium falciparum and Plasmodium vivax is unknown.Methods.A nested case-control study of 467 pregnant women (136 Plasmodium-infected cases and 331 uninfected control subjects) in northwestern Thailand was conducted. Antibody levels to P. falciparum and P. vivax merozoite antigens and the pregnancy-specific PfVAR2CSA antigen were determined at enrollment (median 10 weeks ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jis566

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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/Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Journal Of Infectious Diseases Journal website
Issue:
10
Publication date:
2012-11-15
Acceptance date:
2012-06-21
DOI:
ISSN:
1537-6613 and 0022-1899
Pmid:
22966126
Source identifiers:
350471

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