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New Insights into Acquisition, Boosting, and Longevity of Immunity to Malaria in Pregnant Women

Abstract:

Background. How antimalarial antibodies are acquired and maintained during pregnancy and boosted after reinfection with Plasmodium falciparum and Plasmodium vivax is unknown.Methods.A nested case-control study of 467 pregnant women (136 Plasmodium-infected cases and 331 uninfected control subjects) in northwestern Thailand was conducted. Antibody levels to P. falciparum and P. vivax merozoite antigens and the pregnancy-specific PfVAR2CSA antigen were determined at enrollment (median 10 weeks ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/infdis/jis566

Authors


Fowkes, FJI More by this author
McGready, R More by this author
Simpson, JA More by this author
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/Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Journal Of Infectious Diseases Journal website
Issue:
10
Publication date:
2012-11-15
DOI:
ISSN:
0022-1899 and 1537-6613
Pubs id:
pubs:350471
URN:
uri:0678f64d-cdd5-479e-bcd1-07e00fa96afe
UUID:
0678f64d-cdd5-479e-bcd1-07e00fa96afe
Local pid:
pubs:350471

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