Journal article icon

Journal article

Vps13-Mcp1 interact at vacuole–mitochondria interfaces and bypass ER–mitochondria contact sites

Abstract:

Membrane contact sites between endoplasmic reticulum (ER) and mitochondria, mediated by the ER-mitochondria encounter structure (ERMES) complex, are critical for mitochondrial homeostasis and cell growth. Defects in ERMES can, however, be bypassed by point mutations in the endosomal protein Vps13 or by overexpression of the mitochondrial protein Mcp1. How this bypass operates remains unclear. Here we show that the mitochondrial outer membrane protein Mcp1 functions in the same pathway as Vps1...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1083/jcb.201610055

Authors


More by this author
Role:
Author
ORCID:
0000-0001-8356-5469
More by this author
Role:
Author
ORCID:
0000-0003-4535-5115
More from this funder
Name:
European Research Council
Grant:
337906
Publisher:
Rockefeller University Press
Journal:
Journal of Cell Biology More from this journal
Volume:
216
Issue:
10
Pages:
3219-3229
Publication date:
2017-09-01
Acceptance date:
2017-07-25
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Pmid:
28864540
Language:
English
Keywords:
Pubs id:
pubs:976818
UUID:
uuid:066e1aea-5f44-40d4-bc0d-03a8d219b5ce
Local pid:
pubs:976818
Source identifiers:
976818
Deposit date:
2019-05-10

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP