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Model organisms at the heart of regeneration

Abstract:

Heart failure is a major cause of death worldwide owing to the inability of the adult human heart to regenerate after a heart attack. However, many vertebrate species are capable of complete cardiac regeneration following injury. In this Review, we discuss the various model organisms of cardiac regeneration, and outline what they have taught us thus far about the cellular and molecular responses essential for optimal cardiac repair. We compare across different species, highlighting evolutiona...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dmm.040691

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Department:
Oxford, MSD, Medical Sciences Division
Role:
Author
ORCID:
0000-0003-2023-6304
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0002-9862-7332
Publisher:
Company of Biologists Publisher's website
Journal:
Disease Models and Mechanisms Journal website
Volume:
12
Issue:
10
Article number:
dmm040691
Publication date:
2019-09-27
Acceptance date:
2019-08-13
DOI:
EISSN:
1754-8411
ISSN:
1754-8403
Pmid:
31562250
Language:
English
Keywords:
Pubs id:
pubs:1060485
UUID:
uuid:06453591-e23b-4034-9c5d-177f65ad53d9
Local pid:
pubs:1060485
Source identifiers:
1060485
Deposit date:
2019-10-08

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