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Oral hormone pregnancy tests and the risks of congenital malformations: A systematic review and meta-analysis

Abstract:
Background: Oral hormone pregnancy tests (HPTs), such as Primodos, containing ethinylestradiol and high doses of norethisterone, were given to over a million women from 1958 to 1978, when Primodos was withdrawn from the market because of concerns about possible teratogenicity. We aimed to study the association between maternal exposure to oral HPTs and congenital malformations. Methods: We have performed a systematic review and meta-analysis of case-control a... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.12688/f1000research.16758.1

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care Health Sciences
Oxford college:
Kellogg College
ORCID:
0000-0002-1009-1992
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care Health Sciences
Spencer, E More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Primary Care Health Sciences
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Publisher:
F1000Research Publisher's website
Journal:
F1000Research 2018 Journal website
Pages:
Article: 1725
Publication date:
2018-10-31
Acceptance date:
2018-11-29
DOI:
Pubs id:
pubs:942208
URN:
uri:062fc1dd-e890-4c8f-90e8-9a60e978c244
UUID:
uuid:062fc1dd-e890-4c8f-90e8-9a60e978c244
Local pid:
pubs:942208

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