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Crystal structure of human RIOK2 bound to a specific inhibitor

Abstract:

The RIO kinases (RIOKs) are a universal family of atypical kinases that are essential for assembly of the pre-40S ribosome complex. Here, we present the crystal structure of human RIO kinase 2 (RIOK2) bound to a specific inhibitor. This first crystal structure of an inhibitor-bound RIO kinase reveals the binding mode of the inhibitor and explains the structure-activity relationship of the inhibitor series. The inhibitor binds in the ATP-binding site and forms extensive hydrophobic interaction...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
ORCID:
0000-0003-2858-8929
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Name:
European Commission
Grant:
115766
Publisher:
Royal Society
Journal:
Open Biology More from this journal
Volume:
9
Issue:
4
Article number:
190037
Publication date:
2019-04-17
Acceptance date:
2019-03-20
DOI:
EISSN:
2046-2441
Pmid:
30991936
Language:
English
Keywords:
Pubs id:
pubs:995314
UUID:
uuid:062c26f9-ce90-4ee4-ac2e-143df18d79a5
Local pid:
pubs:995314
Deposit date:
2019-05-03

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