Journal article
Crystal structure of human RIOK2 bound to a specific inhibitor
- Abstract:
-
The RIO kinases (RIOKs) are a universal family of atypical kinases that are essential for assembly of the pre-40S ribosome complex. Here, we present the crystal structure of human RIO kinase 2 (RIOK2) bound to a specific inhibitor. This first crystal structure of an inhibitor-bound RIO kinase reveals the binding mode of the inhibitor and explains the structure-activity relationship of the inhibitor series. The inhibitor binds in the ATP-binding site and forms extensive hydrophobic interaction...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- Royal Society Publisher's website
- Journal:
- Open Biology Journal website
- Volume:
- 9
- Issue:
- 4
- Article number:
- 190037
- Publication date:
- 2019-04-17
- Acceptance date:
- 2019-03-20
- DOI:
- EISSN:
-
2046-2441
- Pmid:
-
30991936
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:995314
- UUID:
-
uuid:062c26f9-ce90-4ee4-ac2e-143df18d79a5
- Local pid:
- pubs:995314
- Deposit date:
- 2019-05-03
Terms of use
- Copyright holder:
- Wang et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record