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Mechano-logical model of C. elegans germ line suggests feedback on the cell cycle

Abstract:

The Caenorhabditis elegans germ line is an outstanding model system in which to study the control of cell division and differentiation. Although many of the molecules that regulate germ cell proliferation and fate decisions have been identified, how these signals interact with cellular dynamics and physical forces within the gonad remains poorly understood. We therefore developed a dynamic, 3D in silico model of the C. elegans germ line, incorporating both the mechanical interactions between ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dev.126359

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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Oxford college:
New College
Role:
Author
ORCID:
0000-0001-8311-3200
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Role:
Author
ORCID:
0000-0001-5893-7232
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Name:
NIH HHS
Grant:
P40 OD010440
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Name:
NIGMS NIH HHS
Grant:
R01 GM061706
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Name:
Engineering and Physical Sciences Research Council
Grant:
1230968
Publisher:
Company of Biologists
Journal:
Development More from this journal
Volume:
142
Issue:
22
Pages:
3902-3911
Publication date:
2015-11-17
Acceptance date:
2015-09-17
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Pmid:
26428008
Language:
English
Keywords:
Pubs id:
pubs:659212
UUID:
uuid:0628e44a-a75f-440e-a24e-4edd1d362639
Local pid:
pubs:659212
Source identifiers:
659212
Deposit date:
2018-04-04

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