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Quantifying the monomer-dimer equilibrium of tubulin with mass photometry

Abstract:

The aB-tubulin heterodimer is the fundamental building block of microtubules, making it central to several cellular processes. Despite the apparent simplicity of heterodimerisation, the associated energetics and kinetics remain disputed, largely due to experimental challenges associated with quantifying affinities in the

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jmb.2020.10.013

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0003-0136-7704
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Name:
European Commission
Grant:
819593
Publisher:
Elsevier
Journal:
Journal of Molecular Biology More from this journal
Volume:
432
Issue:
23
Pages:
6168-6172
Publication date:
2020-10-15
Acceptance date:
2020-10-09
DOI:
ISSN:
0022-2836
Language:
English
Keywords:
Pubs id:
1137792
Local pid:
pubs:1137792
Deposit date:
2020-10-15

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