Journal article
Population pharmacokinetics and cerebrospinal fluid penetration of fluconazole in adults with cryptococcal meningitis
- Abstract:
-
Robust population pharmacokinetic (PK) data for fluconazole are scarce. The variability of fluconazole penetration into the CNS is not known. A fluconazole PK study was conducted in 43 patients receiving oral fluconazole (usually 800 mg q24h) in combination with amphotericin B deoxycholate (1 mg/kg q24h) for cryptococcal meningitis (CM). A 4-compartment PK model was developed and Monte Carlo simulations performed for a range of fluconazole dosages. A meta-analysis of trials reporting outcomes...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 127.7KB)
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1128/aac.00885-18
Authors
Funding
United Kingdom Department for International Development
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Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Antimicrobial Agents and Chemotherapy Journal website
- Volume:
- 62
- Issue:
- 9
- Pages:
- e00885-18
- Publication date:
- 2018-06-18
- Acceptance date:
- 2018-04-27
- DOI:
- EISSN:
-
1098-6596
- ISSN:
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0066-4804
- Pmid:
-
29914943
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:859156
- UUID:
-
uuid:060b1823-ec56-402d-be69-45fd086754f8
- Local pid:
- pubs:859156
- Source identifiers:
-
859156
- Deposit date:
- 2018-07-03
Terms of use
- Copyright holder:
- Stott et al
- Copyright date:
- 2018
- Notes:
- © 2018 Stott et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. A correction to this article is available at: 10.1128/AAC.02254-18
- Licence:
- CC Attribution (CC BY)
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