Journal article
Molecular neurobiological clues to the pathogenesis of bipolar disorder
- Abstract:
-
Bipolar disorder is a serious psychiatric disorder, with a high heritability and unknown pathogenesis. Recent genome-wide association studies have identified the first loci, implicating genes such as CACNA1C and ANK3. The genes highlight several pathways, notably calcium signalling, as being of importance. Molecular studies suggest that the risk variants impact on gene regulation and expression. Preliminary studies using reprogrammed patient-derived cells report alterations in the transcripto...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Current opinion in neurobiology Journal website
- Volume:
- 36
- Pages:
- 1-6
- Publication date:
- 2016-02-01
- DOI:
- EISSN:
-
1873-6882
- ISSN:
-
0959-4388
- Pmid:
-
26210959
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:536692
- UUID:
-
uuid:05f1f64f-0b41-46fe-a401-2f9f448daa78
- Local pid:
- pubs:536692
- Source identifiers:
-
536692
- Deposit date:
- 2017-02-09
Terms of use
- Copyright holder:
- Harrison, P
- Copyright date:
- 2016
- Notes:
- © 2015 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecom-mons.org/licenses/by/4.0/)
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