Journal article icon

Journal article

Molecular neurobiological clues to the pathogenesis of bipolar disorder

Abstract:

Bipolar disorder is a serious psychiatric disorder, with a high heritability and unknown pathogenesis. Recent genome-wide association studies have identified the first loci, implicating genes such as CACNA1C and ANK3. The genes highlight several pathways, notably calcium signalling, as being of importance. Molecular studies suggest that the risk variants impact on gene regulation and expression. Preliminary studies using reprogrammed patient-derived cells report alterations in the transcripto...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Oxford college:
Wolfson College
Role:
Author
Publisher:
Elsevier
Journal:
Current opinion in neurobiology More from this journal
Volume:
36
Pages:
1-6
Publication date:
2016-02-01
DOI:
EISSN:
1873-6882
ISSN:
0959-4388
Pmid:
26210959
Language:
English
Keywords:
Pubs id:
pubs:536692
UUID:
uuid:05f1f64f-0b41-46fe-a401-2f9f448daa78
Local pid:
pubs:536692
Source identifiers:
536692
Deposit date:
2017-02-09

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP