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Virulence associated gene 8 of Bordetella pertussis enhances contact system activity by inhibiting the regulatory function of complement regulator C1 inhibitor

Abstract:

Bordetella pertussis is a Gram-negative bacterium and the causative agent of whooping cough. Whooping cough is currently re-emerging worldwide and, therefore, still poses a continuous global health threat. B. pertussis expresses several virulence factors that play a role in evading the human immune response. One of these virulence factors is virulence associated gene 8 (Vag8). Vag8 is a complement evasion molecule that mediates its effects by binding to the complement regulator C1 inhibitor (...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2018.01172

Authors


Hovingh, ES More by this author
De Maat, S More by this author
Cloherty, APM More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
ORCID:
0000-0002-7877-3543
Pinelli, E More by this author
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Funding agency for:
Johnson, S
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Grant:
016.156.051
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Issue:
JUN
Pages:
Article: 1172
Publication date:
2018-06-04
Acceptance date:
2018-05-11
DOI:
ISSN:
1664-3224
Pubs id:
pubs:857806
URN:
uri:05f1c271-e7ba-4918-b856-869066c393d0
UUID:
uuid:05f1c271-e7ba-4918-b856-869066c393d0
Local pid:
pubs:857806

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