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Virulence associated gene 8 of Bordetella pertussis enhances contact system activity by inhibiting the regulatory function of complement regulator C1 inhibitor

Abstract:

Bordetella pertussis is a Gram-negative bacterium and the causative agent of whooping cough. Whooping cough is currently re-emerging worldwide and, therefore, still poses a continuous global health threat. B. pertussis expresses several virulence factors that play a role in evading the human immune response. One of these virulence factors is virulence associated gene 8 (Vag8). Vag8 is a complement evasion molecule that mediates its effects by binding to the complement regulator C1 inhibitor (...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0002-7877-3543
More from this funder
Name:
Wellcome Trust
Funding agency for:
Johnson, S
Grant:
Investigator Award (100298) awarded to Prof. S.M. Lea
More from this funder
Name:
Rijksinstituut voor Volksgezondheid en Milieu
Grant:
S/112001
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Name:
ZonMw
Grant:
016.156.051
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
9
Issue:
JUN
Article number:
1172
Publication date:
2018-06-04
Acceptance date:
2018-05-11
DOI:
ISSN:
1664-3224
Pmid:
29915576
Language:
English
Keywords:
Pubs id:
pubs:857806
UUID:
uuid:05f1c271-e7ba-4918-b856-869066c393d0
Local pid:
pubs:857806
Source identifiers:
857806
Deposit date:
2018-08-02

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