- Abstract:
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A variable proportion of patients with generalized myasthenia gravis (MG) have autoantibodies to muscle specific tyrosine kinase (MuSK). During development agrin, released from the motor nerve, interacts with low density lipoprotein receptor-related protein-4 (LRP4), which then binds to MuSK; MuSK interaction with the intracellular protein Dok7 results in clustering of the acetylcholine receptors (AChRs) on the postsynaptic membrane. In mature muscle, MuSK helps maintain the high density of A...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 2.1mb)
-
- Publisher copy:
- 10.1371/journal.pone.0080695
-
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- Publisher:
- PLoS Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 8
- Issue:
- 11
- Pages:
- Article:e80695
- Acceptance date:
- 2013-10-13
- DOI:
- EISSN:
-
1932-6203
- Pubs id:
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pubs:440150
- URN:
-
uri:05cd37e3-f384-421f-8f5e-1581a28433ca
- UUID:
-
uuid:05cd37e3-f384-421f-8f5e-1581a28433ca
- Local pid:
- pubs:440150
- Copyright holder:
- Koneczny et al.
- Notes:
- © 2013 Koneczny et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters
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