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Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labelling.

Abstract:

We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Na(v)1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design to assess her baseline erythromelalgia pain vs cooling relief. Robust activations of key pain, pain...

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Publication status:
Published

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Publisher copy:
10.1016/j.pain.2011.12.012

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Pain
Volume:
153
Issue:
5
Pages:
1122-1127
Publication date:
2012-05-05
DOI:
EISSN:
1872-6623
ISSN:
0304-3959
URN:
uuid:05cc8809-6e08-450b-92cc-48bbcae163b0
Source identifiers:
313037
Local pid:
pubs:313037

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