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Tumor necrosis factor inhibits spread of hepatitis C virus among liver cells, independent from interferons

Abstract:

BACKGROUND & AIMS: Tumor necrosis factor (TNF) an inflammatory cytokine expressed by human fetal liver cells (HFLCs) following infection with cell culture-derived hepatitis C virus. TNF has been reported to increase entry of HCV pseudoparticles into hepatoma cells and inhibit signaling by interferon alpha (IFNA), but have no effect on replication of HCV RNA. We investigated the effects of TNF on HCV infection of and spread among Huh-7 hepatoma cells and primary HFLCs.  METHODS: Human hepa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1053/j.gastro.2017.04.021

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More from this funder
Name:
National Institutes of Health
Grant:
R01AI072613toC.M.R
R01CA057973
Publisher:
AGA Institute
Journal:
Gastroenterology More from this journal
Volume:
153
Issue:
2
Pages:
566-578.e5
Publication date:
2017-04-26
Acceptance date:
2017-04-21
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
Language:
English
Keywords:
Pubs id:
pubs:692133
UUID:
uuid:05c4e269-1e61-4310-9ed8-4dae78100c56
Local pid:
pubs:692133
Source identifiers:
692133
Deposit date:
2017-06-08

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