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Are large simple trials for dementia prevention possible?

Abstract:

New trials of dementia prevention are needed to test novel strategies and agents. Large, simple, cardiovascular trials have successfully discovered treatments with moderate but worthwhile effects to prevent heart attack and stroke. The design of these trials may hold lessons for the dementia prevention. Here we outline suitable populations, interventions and outcomes for large simple trials in dementia prevention. We consider what features are needed to maximise efficiency. Populations could...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Name:
Alberta Innovates
Grant:
201300690
Publisher:
Oxford University Press
Journal:
Age and Ageing More from this journal
Volume:
49
Issue:
2
Pages:
154-160
Publication date:
2019-12-12
Acceptance date:
2019-07-30
DOI:
EISSN:
1468-2834
ISSN:
0002-0729
Pmid:
31830268
Language:
English
Keywords:
Pubs id:
1078096
Local pid:
pubs:1078096
Deposit date:
2020-04-03

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