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The transmembrane domain of the SNARE protein VAMP2 is highly sensitive to its lipid environment

Abstract:

Neurotransmitter and hormone exocytosis depends on SNARE protein transmembrane domains and membrane lipids but their interplay is poorly understood. We investigated the interaction of the structure of VAMP2, a vesicular transmembrane SNARE protein, and membrane lipid composition by infrared spectroscopy using either the wild-type transmembrane domain (TMD), VAMP2TM22, or a peptide mutated at the central residues G100/C103 (VAMP2TM22VV) previously identified by us as being critical for exocyto...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbamem.2018.12.011

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
ORCID:
0000-0003-1244-7857
Publisher:
Elsevier
Journal:
Biochimica et Biophysica Acta (BBA) - Biomembranes More from this journal
Volume:
1861
Issue:
3
Pages:
670-676
Publication date:
2018-12-20
Acceptance date:
2018-12-17
DOI:
EISSN:
1879-2642
ISSN:
0005-2736
Pmid:
30579961
Language:
English
Keywords:
Pubs id:
pubs:956030
UUID:
uuid:05c416c0-7f88-4d9a-8392-52bff07d600f
Local pid:
pubs:956030
Source identifiers:
956030
Deposit date:
2019-01-30

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