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Association of impaired cytochrome P450 2D6 activity genotype and phenotype with therapeutic efficacy of primaquine treatment for latent Plasmodium vivax malaria

Abstract:
Importance Latent hepatic Plasmodium vivax hypnozoites provoke repeated clinical attacks called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity may depend on naturally polymorphic cytochrome P450 2D6 isotype (CYP2D6) activity. Objective To examine the association of impaired CYP2D6 genotypes and CYP2D6 metabolic phenotypes with therapeutic failure of directly observed high-dose primaquine treatment for P vivax malaria re... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1001/jamanetworkopen.2018.1449

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Role:
Author
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Bill and Melinda Gates Foundation More from this funder
Medicines for Malaria Venture More from this funder
Publisher:
American Medical Association Publisher's website
Journal:
JAMA Network Open Journal website
Volume:
1
Issue:
4
Pages:
Article: e181449
Publication date:
2018-08-31
Acceptance date:
2018-04-30
DOI:
ISSN:
2574-3805
Pubs id:
pubs:847204
URN:
uri:059e8117-02ab-4bfb-9d7c-197b943c85a0
UUID:
uuid:059e8117-02ab-4bfb-9d7c-197b943c85a0
Local pid:
pubs:847204

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