Journal article icon

Journal article

Association of impaired cytochrome P450 2D6 activity genotype and phenotype with therapeutic efficacy of primaquine treatment for latent Plasmodium vivax malaria

Abstract:
Importance Latent hepatic Plasmodium vivax hypnozoites provoke repeated clinical attacks called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity may depend on naturally polymorphic cytochrome P450 2D6 isotype (CYP2D6) activity. Objective To examine the association of impaired CYP2D6 genotypes and CYP2D6 metabolic phenotypes with therapeutic failure of directly observed high-dose primaquine treatment for P vivax malaria re... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1001/jamanetworkopen.2018.1449

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Expand authors...
Bill and Melinda Gates Foundation More from this funder
Medicines for Malaria Venture More from this funder
Publisher:
American Medical Association Publisher's website
Journal:
JAMA Network Open Journal website
Volume:
1
Issue:
4
Article number:
e181449
Publication date:
2018-08-31
Acceptance date:
2018-04-30
DOI:
ISSN:
2574-3805
Source identifiers:
847204
Pubs id:
pubs:847204
UUID:
uuid:059e8117-02ab-4bfb-9d7c-197b943c85a0
Local pid:
pubs:847204
Deposit date:
2018-05-11

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP