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Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states

Abstract:

Brown adipose tissue (BAT) is a potential target to treat cardiometabolic disorders because of its capacity to combust glucose and fatty acids for thermoregulation. Its cellular and molecular investigation in humans is hampered by the limited availability of cell material and the heterogeneity of BAT between and within individuals. In this study, monoclonal lines of conditionally immortalized brown preadipocytes (iBPAs) of mouse and human origin were generated. Conditional immortalization was...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbalip.2019.08.007

Authors


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Name:
British Heart Foundation
Grant:
RG/17/1/32663
Publisher:
Elsevier
Journal:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids More from this journal
Volume:
1864
Issue:
12
Article number:
158511
Publication date:
2019-08-26
Acceptance date:
2019-08-20
DOI:
EISSN:
1879-2618
ISSN:
1388-1981
Pmid:
31465889
Language:
English
Keywords:
Pubs id:
pubs:1048795
UUID:
uuid:05997f0c-52c4-46b6-a931-31453b6deece
Local pid:
pubs:1048795
Source identifiers:
1048795
Deposit date:
2019-11-08

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