Journal article
ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration.
- Abstract:
-
Animals have evolved multiple mechanisms to protect themselves from the cumulative effects of age-related cellular damage. Here, we reveal an unexpected link between the TNF (tumour necrosis factor) inflammatory pathway, triggered by the metalloprotease ADAM17/TACE, and a lipid droplet (LD)-mediated mechanism of protecting retinal cells from age-related degeneration. Loss of ADAM17, TNF and the TNF receptor Grindelwald in pigmented glial cells of the Drosophila retina leads to age-related deg...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Deutsche Forschungsgemeinschaft (DFG)
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Bibliographic Details
- Publisher:
- EMBO Publisher's website
- Journal:
- EMBO Journal Journal website
- Volume:
- 39
- Issue:
- 17
- Article number:
- e104415
- Place of publication:
- England
- Publication date:
- 2020-07-26
- Acceptance date:
- 2020-06-29
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- Pmid:
-
32715522
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1123063
- Local pid:
- pubs:1123063
- Deposit date:
- 2020-10-20
Terms of use
- Copyright holder:
- Muliyil et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors. Published under the terms of the CC BY 4.0 license.
- Licence:
- CC Attribution (CC BY)
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