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Journal article

The nuts and bolts of the Haloferax CRISPR-Cas system I-B

Abstract:

Invading genetic elements pose a constant threat to prokaryotic survival, requiring an effective defence. Eleven years ago, the arsenal of known defence mechanisms was expanded by the discovery of the CRISPR-Cas system. Although CRISPR-Cas is present in the majority of archaea, research often focuses on bacterial models. Here, we provide a perspective based on insights gained studying CRISPR-Cas system I-B of the archaeon Haloferax volcanii. The system relies on more than 50 different crRNAs,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1080/15476286.2018.1460994

Authors


Maier, L-K More by this author
Stachler, A-E More by this author
Brendel, J More by this author
Fischer, S More by this author
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Publisher:
Taylor & Francis Publisher's website
Journal:
RNA Biology Journal website
Volume:
16
Issue:
4
Pages:
469-48
Publication date:
2018-05-21
Acceptance date:
2018-03-30
DOI:
EISSN:
1555-8584
ISSN:
1547-6286
Pubs id:
pubs:840546
URN:
uri:057eab9e-354e-4cd7-b310-9f97096aa2a8
UUID:
uuid:057eab9e-354e-4cd7-b310-9f97096aa2a8
Local pid:
pubs:840546

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