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Journal article

DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility

Abstract:
Aim of the study A vast majority of human malignancies are associated with ageing, and age is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing, known as ‘epigenetic clock’, has been linked with cancer risk factors. This study aimed to evaluate whether the epigenetic clock is associated with breast cancer risk susceptibility and to identify potential epigenetics-based biomarkers for risk stratification. Methods Here, we prof... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.ejca.2017.01.014

Authors


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ORCID:
0000-0003-3102-3603
Horvath, S More by this author
Perrier, F More by this author
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ORCID:
0000-0001-6045-2103
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Grant:
Seventh Framework Programme (FP7 Exposomics) (308610-2) Translational Cancer Research (TRANSCAN) (TRANS201301184) Framework
Fondation Association pour la Recherche contre le Cancer More from this funder
Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
European Journal of Cancer Journal website
Volume:
75
Pages:
299-307
Publication date:
2017-02-28
Acceptance date:
2017-01-20
DOI:
EISSN:
1879-0852
ISSN:
0959-8049
Pubs id:
pubs:685316
URN:
uri:057c08c0-5cac-488a-915b-c87b66d95cf6
UUID:
uuid:057c08c0-5cac-488a-915b-c87b66d95cf6
Local pid:
pubs:685316

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