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One-pot, Three-Component Sulfonimidamide Synthesis exploiting the Sulfinylamine Reagent N-Sulfinyltritylamine, TrNSO

Abstract:

Sulfonimidamides are increasingly important molecules in medicinal chemistry and agrochemistry, but their preparation requires lengthy synthetic sequences, which has likely limited their use. We describe a one‐pot de novo synthesis of sulfonimidamides from widely available organometallic reagents and amines. This convenient and efficient process uses a stable sulfinylamine reagent, N‐sulfinyltritylamine (TrNSO), available in one step on 10 gram scale, as a linchpin. In contrast to classical a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1002/ange.201708590

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Department:
Lincoln College
Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie International Edition Journal website
Volume:
129
Issue:
47
Pages:
15133-15137
Publication date:
2017-09-19
Acceptance date:
2017-09-19
DOI:
EISSN:
1521-3757
ISSN:
1433-7851
Pubs id:
pubs:729906
URN:
uri:05721659-7b08-4346-a26e-606684ac10db
UUID:
uuid:05721659-7b08-4346-a26e-606684ac10db
Local pid:
pubs:729906

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