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Journal article

Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate-amodiaquine fixed dose combination or artemether-lumefantrine in Liberia

Abstract:

Plasmodium falciparum uncomplicated malaria can successfully be treated with an artemisinin-based combination therapy (ACT). However resistance is spreading to the different ACT compounds; the artemisinin derivative and the partner drug. Studies of P. falciparum polymorphisms associated with drug resistance can provide a useful tool to track resistance and guide treatment policy as well as an in-depth understanding of the development and spread of resistance.The role of P. falciparum molecula...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-016-1503-3

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Drugs for Neglected Diseases initiative More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Malaria journal Journal website
Volume:
15
Issue:
452
Pages:
1-6
Publication date:
2016-09-05
Acceptance date:
2016-08-26
DOI:
ISSN:
1475-2875
Pmid:
27596849
Source identifiers:
642227

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