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Thesis

Characterisation of the murine gene and the porcine cDNA for lung surfactant Protein D and genetic mapping of murine complement components using a novel approach

Abstract:

The work in this thesis describes the isolation and characterisation of the mouse surfactant protein D (SP-D) gene (Sftpd). This gene has been show to span 8 exons across 14 kb of DNA sequence and displays an overall organisation similar to the other collectin genes. The complete 5' untranslated region of the mRNA was also cloned which allowed the identification of the transcription start site for SP-D. Subsequently, the analysis of the promoter region of Sftpd revealed p...

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Peer review status:
Peer reviewed

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Department:
University of Oxford
Role:
Author
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Source identifiers:
603847155
UUID:
uuid:050fecd9-5cd7-4928-b81b-8f9dffee56fc
Local pid:
polonsky:5:7
Deposit date:
2017-10-05

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