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Development and evaluation of a non-ribosomal random PCR and next-generation sequencing based assay for detection and sequencing of hand, foot and mouth disease pathogens

Abstract:

Hand, foot and mouth disease (HFMD) has become a major public health problem across the Asia-Pacific region, and is commonly caused by enterovirus A71 (EV-A71) and coxsackievirus A6 (CV-A6), CV-A10 and CV-A16. Generating pathogen whole-genome sequences is essential for understanding their evolutionary biology. The frequent replacements among EV serotypes and a limited numbers of available whole-genome sequences hinder the development of overlapping PCRs for whole-genome sequencing. We develop...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12985-016-0580-9

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Publisher:
BioMed Central Publisher's website
Journal:
Virology Journal Journal website
Volume:
13
Issue:
125
Pages:
1-10
Publication date:
2016-07-07
Acceptance date:
2016-06-29
DOI:
ISSN:
1743-422X
Pubs id:
pubs:634002
URN:
uri:04b81308-41ae-4406-886a-8dcbee093124
UUID:
uuid:04b81308-41ae-4406-886a-8dcbee093124
Local pid:
pubs:634002

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