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Convalescent plasma donors show enhanced cross-reactive neutralizing antibody response to antigenic variants of SARS-CoV-2 following immunization

Abstract:
Background The therapeutic benefit of convalescent plasma (CP) therapy to treat COVID-19 may derive from neutralizing antibodies (nAbs) to SARS-CoV-2. To investigate the effects of antigenic variation on neutralization potency of CP, we compared nAb titers against prototype and recently emerging strains of SARS-CoV-2, including Delta and Omicron, in CP donors previously infected with SARS-CoV-2 before and after immunization.
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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/trf.16934

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Role:
Author
ORCID:
0000-0001-9154-4190
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Role:
Author
ORCID:
0000-0002-7964-4700
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Publisher:
Wiley Publisher's website
Journal:
Transfusion Journal website
Publication date:
2022-06-02
Acceptance date:
2022-04-19
DOI:
EISSN:
1537-2995
ISSN:
0041-1132
Pmid:
35588314
Language:
English
Keywords:
Pubs id:
1260215
Local pid:
pubs:1260215
Deposit date:
2022-06-23

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