Journal article icon

Journal article

Bone mineral density and risk of type 2 diabetes and coronary heart disease: A Mendelian randomization study

Abstract:

Background: Observational studies have demonstrated that increased bone mineral density is associated with a higher risk of type 2 diabetes (T2D), but the relationship with risk of coronary heart disease (CHD) is less clear. Moreover, substantial uncertainty remains about the causal relevance of increased bone mineral density for T2D and CHD, which can be assessed by Mendelian randomisation studies.  Methods: We identified 235 independent single nucleotide polymorphisms (SNPs) associated at p...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
National Institute for Health Research
Grant:
Oxford Biomedical Research Centre (BRC
More from this funder
Name:
National Institute of Diabetes and Digestive and Kidney Diseases
Grant:
U01-DK085545/
More from this funder
Name:
Wellcome Trust
Grant:
090532]toMM
098381]
Publisher:
F1000Research
Journal:
Wellcome Open Research More from this journal
Volume:
2
Article number:
68
Publication date:
2017-08-22
Acceptance date:
2017-08-22
DOI:
ISSN:
2398-502X
Pmid:
28989980
Language:
English
Keywords:
Pubs id:
pubs:736914
UUID:
uuid:0458d1c0-c5a0-49f7-ab6f-e2112948662a
Local pid:
pubs:736914
Source identifiers:
736914
Deposit date:
2017-11-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP