Journal article
Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria
- Abstract:
-
X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. The severe Mediterranean variant (G6PD Med) found across Europe and Asia is thought to confer protection against malaria, but its effect is unclear. We fitted a Bayesian statistical model to observed G6PD Med allele frequencies in 999 Pashtun patients presenting with acute Plasmodium vivax malaria and 1408 population controls. G6PD Med was associated with reductions in symptomatic P. vivax malar...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust: Principle Fellowship of NJ White
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Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 10
- Article number:
- e62448
- Place of publication:
- England
- Publication date:
- 2021-02-15
- Acceptance date:
- 2021-02-03
- DOI:
- EISSN:
-
2050-084X
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1161221
- Local pid:
- pubs:1161221
- Deposit date:
- 2021-03-12
Terms of use
- Copyright holder:
- GR Awab et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright Awab et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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