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Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles

Abstract:

Although host genetics influences susceptibility to tuberculosis (TB), few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of Mycobacterium tuberculosis (Mtb) infection would have distinct gene expression profiles and that polymorphisms in these genes may also be associated with susceptibility to TB. We measured gene expression levels of >38,500 genes from ex vivo Mtb...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.ppat.1000229

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Research group:
Vietnam/OUCRU
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Research group:
Vietnam/OUCRU
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Research group:
Vietnam/OUCRU
Role:
Author
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Funding agency for:
Dunstan, SJ
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Funding agency for:
Farrar, JJ
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Publisher:
PLoS Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
4
Issue:
12
Pages:
Article: e1000229
Publication date:
2008-12-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pubs id:
pubs:92797
URN:
uri:0426f081-e8e7-4eba-be60-c570ee245422
UUID:
uuid:0426f081-e8e7-4eba-be60-c570ee245422
Local pid:
pubs:92797
Keywords:

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