- Abstract:
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Although host genetics influences susceptibility to tuberculosis (TB), few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of Mycobacterium tuberculosis (Mtb) infection would have distinct gene expression profiles and that polymorphisms in these genes may also be associated with susceptibility to TB. We measured gene expression levels of >38,500 genes from ex vivo Mtb...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 259.1KB)
-
- Publisher copy:
- 10.1371/journal.ppat.1000229
-
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- Funding agency for:
- Hibberd, M
- Funding agency for:
- Seielstad, M
- Publisher:
- PLoS Publisher's website
- Journal:
- PLoS Pathogens Journal website
- Volume:
- 4
- Issue:
- 12
- Pages:
- Article: e1000229
- Publication date:
- 2008-12-05
- DOI:
- EISSN:
-
1553-7374
- ISSN:
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1553-7366
- Pubs id:
-
pubs:92797
- URN:
-
uri:0426f081-e8e7-4eba-be60-c570ee245422
- UUID:
-
uuid:0426f081-e8e7-4eba-be60-c570ee245422
- Local pid:
- pubs:92797
- Keywords:
- Copyright holder:
- Thuong et al.
- Copyright date:
- 2008
- Notes:
- © 2008 Thuong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles
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+ Agency for Science Technology and Research, Singapore
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