Journal article
Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles
- Abstract:
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Although host genetics influences susceptibility to tuberculosis (TB), few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of Mycobacterium tuberculosis (Mtb) infection would have distinct gene expression profiles and that polymorphisms in these genes may also be associated with susceptibility to TB. We measured gene expression levels of >38,500 genes from ex vivo Mtb...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 259.1KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.ppat.1000229
Authors
Funding
+ Agency for Science Technology and Research, Singapore
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Funding agency for:
Hibberd, M
Seielstad, M
Bibliographic Details
- Publisher:
- PLoS
- Journal:
- PLoS Pathogens More from this journal
- Volume:
- 4
- Issue:
- 12
- Article number:
- e1000229
- Publication date:
- 2008-12-05
- Acceptance date:
- 2008-11-05
- DOI:
- EISSN:
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1553-7374
- ISSN:
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1553-7366
- Pmid:
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19057661
Item Description
- Keywords:
- Pubs id:
-
pubs:92797
- UUID:
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uuid:0426f081-e8e7-4eba-be60-c570ee245422
- Local pid:
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pubs:92797
- Source identifiers:
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92797
- Deposit date:
-
2017-05-03
Terms of use
- Copyright holder:
- Thuong et al
- Copyright date:
- 2008
- Notes:
- © 2008 Thuong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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