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Structure-based classification defines the discrete conformational classes adopted by the arenaviral GP1

Abstract:

The emergence of Old and New World arenaviruses from rodent reservoirs persistently threatens human health. The GP1 subunit of the envelope-displayed arenaviral glycoprotein spike complex, GPC, mediates host-cell recognition and is an important determinant of cross-species transmission. Previous structural analyses of Old World arenaviral GP1 glycoproteins, alone and in complex with a cognate GP2 subunit, have revealed that GP1 adopts two distinct conformational states, distinguished by diffe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/jvi.01048-18

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Structural Biology
Role:
Author
ORCID:
0000-0001-8824-9721
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
MSD Doctoral Training Centre
Role:
Author
ORCID:
0000-0001-8218-5544
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Funding agency for:
Ng, WM
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Grant:
MR/L009528/1
MR/N002091/1
Publisher:
American Society of Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
93
Issue:
1
Pages:
e01048-18
Publication date:
2018-12-10
Acceptance date:
2018-09-28
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Pubs id:
pubs:927654
URN:
uri:03f8b729-1737-43ed-bb4d-e2c650a340e6
UUID:
uuid:03f8b729-1737-43ed-bb4d-e2c650a340e6
Local pid:
pubs:927654

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