Journal article
Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques
- Abstract:
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BACKGROUND: The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset of symptoms. METHODS: We performed a proteomics comparison of the vascular extracellular matrix and associated molecules in human carotid endarterectomy specimens from 6 symptomatic versus 6 asympto...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.4MB)
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- Publisher copy:
- 10.1172/JCI86924
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Authors
Funding
King's BHF Centre of Research Excellence
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+ National Institute for Health Research
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Grant:
BiomedicalResearchCenter
basedatGuy’s
King’sCollegeLondonin
partnershipwithKing’sCollegeHospital
StThomas’NHSFoundationTrust
British Heart Foundation
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Federal Ministry for Transport, Innovation and Technology, Austria
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Federal Ministry of Science, Research and Economy, Austria
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Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- Journal of Clinical Investigation Journal website
- Volume:
- 127
- Issue:
- 4
- Pages:
- 1546-1560
- Publication date:
- 2017-03-20
- Acceptance date:
- 2017-01-19
- DOI:
- EISSN:
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1558-8238
- ISSN:
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0021-9738
- Source identifiers:
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687025
Item Description
- Language:
- English
- Pubs id:
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pubs:687025
- UUID:
-
uuid:03ed4e95-27cb-4880-b045-22a1a75a6977
- Local pid:
- pubs:687025
- Deposit date:
- 2017-04-27
Terms of use
- Copyright holder:
- Langley et al
- Copyright date:
- 2017
- Notes:
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Copyright © 2017 Langley et al. This work is licensed under the Creative Commons Attribution 4.0 International
License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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