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Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques

Abstract:

BACKGROUND: The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset of symptoms. METHODS: We performed a proteomics comparison of the vascular extracellular matrix and associated molecules in human carotid endarterectomy specimens from 6 symptomatic versus 6 asympto...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1172/JCI86924

Authors


Langley, SR More by this author
Willeit, K More by this author
Didangelos, A More by this author
Skroblin, P More by this author
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British Heart Foundation More from this funder
King's BHF Centre of Research Excellence More from this funder
More from this funder
Grant:
Biomedical Research Center based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London in partnership with King’s College Hospital
Federal Ministry for Transport, Innovation and Technology, Austria More from this funder
Federal Ministry of Science, Research and Economy, Austria More from this funder
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
127
Issue:
4
Pages:
1546-1560
Publication date:
2017-03-20
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pubs id:
pubs:687025
URN:
uri:03ed4e95-27cb-4880-b045-22a1a75a6977
UUID:
uuid:03ed4e95-27cb-4880-b045-22a1a75a6977
Local pid:
pubs:687025
Language:
English

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