- Abstract:
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BACKGROUND: The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset of symptoms. METHODS: We performed a proteomics comparison of the vascular extracellular matrix and associated molecules in human carotid endarterectomy specimens from 6 symptomatic versus 6 asympto...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 2.4mb)
-
- Publisher copy:
- 10.1172/JCI86924
-
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- Grant:
- Biomedical Research Center based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London in partnership with King’s College Hospital
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- Journal of Clinical Investigation Journal website
- Volume:
- 127
- Issue:
- 4
- Pages:
- 1546-1560
- Publication date:
- 2017-03-20
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- Pubs id:
-
pubs:687025
- URN:
-
uri:03ed4e95-27cb-4880-b045-22a1a75a6977
- UUID:
-
uuid:03ed4e95-27cb-4880-b045-22a1a75a6977
- Local pid:
- pubs:687025
- Language:
- English
- Copyright holder:
- Langley et al.
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 Langley et al. This work is licensed under the Creative Commons Attribution 4.0 International
License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques
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British Heart Foundation
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King's BHF Centre of Research Excellence
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+ National Institute for Health Research
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Federal Ministry for Transport, Innovation and Technology, Austria
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Federal Ministry of Science, Research and Economy, Austria
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